Cancer models are indispensable research tools, as they help elucidating the mechanisms involved in tumour onset and progression, leading to the development of new therapeutic treatments. While widely-used conventional two-dimensional cell models have been the gold standard for many decades, some of their main limitations include the lack of representation of the stromal population, the absence of a three-dimensional structure, and a poor representation of inter-tumour and intra-tumour heterogeneity. Therefore, a multitude of novel cancer models are emerging, which can advance the understanding of tumour pathophysiology and behavior. This will ultimately help improving patients’ clinical outcomes, through the introduction of more personalized and targeted treatments in the clinical setting.
In recognition of the growing field of research, BMC Cancer welcomes submissions to a newly launched collection ‘Advances in pre-clinical cancer models’. Topics of interest for this special issue include but are not limited to:
- Scaffold-based in vitro models
- 3D cell cultures
- Co-culture settings
- Tumour organoids
- Large and small animal models
- Genetically engineered cell lines and animal models
- Chemically induced tumour models
- Xenotransplantation models (Patient derived xenografts, cell-line derived xenograft)
- Allotransplantation models
This Collection is now open for submissions!
This Collection welcomes submission of Research Articles. Review Articles will be considered at the discretion of the Journal’s Editor. If you would like to submit a Review Article, please first email Chiara Cilibrasi <firstname.lastname@example.org> – the co-Editor of BMC Cancer. Please note that unsolicited reviews will not be considered as per our submission guidelines.
Data sets and descriptions relevant to the Collection will be considered in BMC Research Notes as Data Notes. You can find out more about this article type here. This type of content will be published in BMC Research Notes and included in the final Collection.
Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select “Advances in pre-clinical cancer models” from the dropdown menu. Please ensure you highlight in your cover letter that you are submitting to a Collection.
Submission deadline: 30th of April 2023.