A setback for arthritis gene therapy

The first death of a patient involved in a trial of gene therapy for rheumatoid arthritis is discussed in a commentary in the current issue of Arthritis Research & Therapy. Prof Chris Evans and colleagues have collated information about the clinical trial – put on hold following the patient’s death and since restarted with a modified protocol – and discuss it in the wider context of arthritis gene therapy.


Arthritis gene therapy’s first death
Christopher H Evans, Steven C Ghivizzani, Paul D Robbins
Arthritis Research & Therapy 2008, 10:110 (27 May 2008)
[Abstract] [Full text] [PDF]

This commentary has been made free to access immediately on publication. Arthritis Research & Therapy’s
reviews and commentaries normally require a subscription for access. If
you do not currently have a subscription to the journal you can
register for a free 30-day trial.

Arthritis Research & Therapy is an international,
peer-reviewed online and print journal edited by Prof Peter E Lipsky (USA) and Prof
Sir Ravinder N Maini (UK). The major focus of the journal is in mechanisms of, and translational
laboratory and clinical research into localised and systemic
immune-inflammatory and degenerative diseases of the musculoskeletal
system. Phase I, II and III clinical trials are also published. All research articles published in the journal are open access.

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